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Akesis Gemini360RT  Clinical Value

Innovating radiation medicine

The Akesis Gemini360RT is the first radiotherapy platform to integrate a high-throughput FFF LINAC with a whole-body rotational Gamma system. The LINAC system is designed to support the full range of modern radiotherapy techniques, including 3DCRT, IMRT, VMAT, SRS/FSRT, SBRT/SABR, and Online Adaptive RT. The addition of the optional Gamma head is intended to extend the platform’s stereotactic capabilities, enabling high-precision intracranial and extracranial treatments with steep dose fall-off and nuanced dose painting. Together, the two modalities are designed to offer a level of treatment versatility not previously available on a single platform.

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In addition to supporting most conventional radiotherapy treatments, the technical design of the Akesis Gemini360RT may offer distinctive capabilities relevant to more specialized treatments, particularly Spatially Fractionated Radiation Therapy (SFRT)*. The system’s dosimetric flexibility and dual-modality delivery are characteristics that may be of particular interest in treatment scenarios involving primary tumors with regional or distant metastases, including cases with lymph node involvement or pulmonary oligometastases.

The Gemini360RT is designed to support approaches such as local dose painting, dose escalation to targeted subvolumes including hypoxic regions within locally advanced tumors, and simultaneous irradiation of adjacent at-risk areas. These design characteristics may also lend themselves to grid and lattice irradiation techniques for large or late-stage tumors where conventional fractionation has shown limited response*.

Akesis welcomes collaboration with clinical centers interested in prospective research to rigorously evaluate these potential applications and their benefit to patients.

Case 1**

Metastasis in neck and mediastinal lymph nodes, plus lung oligometastasis (Gemini360RT on left)

Case 2**

Liver cancer (Gemini360RT on left)

Case 3**

Brain metastasis of lung cancer (Gemini360RT on left)

The Gemini360RT’s integrated X-ray and Gamma radiation delivery may offer a meaningful advantage in local dose escalation and asynchronous boost techniques*. Delivering both modalities within a single treatment session is designed to streamline clinical workflow, eliminating the need for multiple setups, reducing treatment planning complexity, and removing a potential source of setup error associated with separate treatment sessions.

Integrated imaging guidance, including real-time kilovoltage (kV) imaging during treatment, is designed to support targeting accuracy and delivery efficiency throughout the treatment process.

Over a century of progress in radiation oncology has brought meaningful advances in the treatment of cancer, and the Gemini360RT represents a new approach within that continuum. Its integrated X-ray and Gamma delivery platform offers a distinct set of technical capabilities with the potential to broaden treatment options and shift how certain complex cases are approached. As clinical experience with the platform grows, Akesis remains committed to supporting the research and collaboration needed to realize that potential for patients.

*The clinical value of applying these techniques on the Akesis Gemini360RT platform has not been established through published clinical data.

**Treatment planning studies only. These plans were developed to illustrate the dosimetric capabilities of the Gemini360RT platform and do not represent treated patients or published clinical outcomes.